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1

Complex coacervates of hyaluronic acid and lysozyme: Effect on protein structure and physical stability

Water, Jorrit J., Schack, Malthe M., Velazquez-Campoy, Adrian, Maltesen, Morten J., van de Weert, Marco, Jorgensen, Lene

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2014

Language:

english

File:

PDF, 616 KB

english, 2014

2

Identification of Novel Inhibitors of the SARS Coronavirus Main Protease 3CL pro†

Bacha, Usman, Barrila, Jennifer, Velazquez-Campoy, Adrian, Leavitt, Stephanie A., Freire, Ernesto

Journal:

Year:

2004

Language:

english

File:

PDF, 214 KB

english, 2004

3

Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition

Elena-Real, Carlos A., Díaz-Quintana, Antonio, González-Arzola, Katiuska, Velázquez-Campoy, Adrián, Orzáez, Mar, López-Rivas, Abelardo, Gil-Caballero, Sergio, De la Rosa, Miguel Á., Díaz-Moreno, Irene

Journal:

Cell Death and Disease

Year:

2018

Language:

english

File:

PDF, 1.39 MB

english, 2018

4

Incorporating target heterogeneity in drug design

Adrian Velazquez-Campoy, Ernesto Freire

Journal:

Journal of Cellular Biochemistry

Year:

2001

Language:

english

File:

PDF, 185 KB

english, 2001

5

Thermodynamics of zinc binding to hepatitis C virus NS3 protease: A folding by binding event

Olga Abian, Jose Luis Neira, Adrian Velazquez-Campoy

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2009

Language:

english

File:

PDF, 325 KB

english, 2009

6

New Measuring Method in Isothermal Titration Calorimetry Based on a Proportional-Integral Controlled System

A. Velázquez-Campoy, O. López-Mayorga, M. A. Cabrerizo-Vílchez

Journal:

Journal of Thermal Analysis and Calorimetry

Year:

1998

File:

PDF, 576 KB

1998

7

HIV-1 Protease Inhibitors: Enthalpic versus Entropic Optimization of the Binding Affinity †

Velazquez-Campoy, Adrian, Todd, Matthew J., Freire, Ernesto

Journal:

Year:

2000

Language:

english

File:

PDF, 299 KB

english, 2000

8

LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat

Martínez-Oliván, Juan, Arias-Moreno, Xabier, Velazquez-Campoy, Adrián, Millet, Oscar, Sancho, Javier

Journal:

Year:

2014

Language:

english

File:

PDF, 892 KB

english, 2014

9

A look at ligand binding thermodynamics in drug discovery

Claveria-Gimeno, Rafael, Vega, Sonia, Abian, Olga, Velazquez-Campoy, Adrian

Journal:

Expert Opinion on Drug Discovery

Year:

2017

Language:

english

File:

PDF, 1.15 MB

english, 2017

10

Cyanobacterial electron carrier proteins as electron donors to CYP106A2 from Bacillus megaterium ATCC 13368

Guillermina Goñi, Andy Zöllner, Michael Lisurek, Adrián Velázquez-Campoy, Sira Pinto, Carlos Gómez-Moreno, Frank Hannemann, Rita Bernhardt, Milagros Medina

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2009

Language:

english

File:

PDF, 762 KB

english, 2009

11

The isolated major homology region of the HIV capsid protein is mainly unfolded in solution and binds to the intact protein

Rosa Doménech, Rebeca Bocanegra, Adrián Velázquez-Campoy, José L. Neira

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2011

Language:

english

File:

PDF, 689 KB

english, 2011

12

Ligand binding to one-dimensional lattice-like macromolecules: Analysis of the McGhee–von Hippel theory implemented in isothermal titration calorimetry

Adrián Velázquez-Campoy

Journal:

Analytical Biochemistry

Year:

2006

Language:

english

File:

PDF, 331 KB

english, 2006

13

Partition of amphiphilic molecules to lipid bilayers by isothermal titration calorimetry

Maria João Moreno, Margarida Bastos, Adrian Velazquez-Campoy

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 242 KB

english, 2010

14

The application of thermodynamic methods in drug design

Adrian Velazquez-Campoy, Irene Luque, Ernesto Freire

Journal:

Thermochimica Acta

Year:

2001

Language:

english

File:

PDF, 291 KB

english, 2001

15

A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease

Sonia Vega, Lin-Woo Kang, Adrian Velazquez-Campoy, Yoshiaki Kiso, L. Mario Amzel, Ernesto Freire

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2004

Language:

english

File:

PDF, 291 KB

english, 2004

16

Thermodynamics of protein-cation interaction: Ca+2 and Mg+2 binding to the fifth binding module of the LDL receptor

Xabier Arias-Moreno, Santiago Cuesta-Lopez, Oscar Millet, Javier Sancho, Adrian Velazquez-Campoy

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2010

Language:

english

File:

PDF, 265 KB

english, 2010

17

Isothermal titration calorimetry to determine association constants for high-affinity ligands

Velazquez-Campoy, Adrian, Freire, Ernesto

Journal:

Nature Protocols

Year:

2006

Language:

english

File:

PDF, 272 KB

english, 2006

18

Determination of the Rigorous Transfer Function of An Isothermal Titration Microcalorimeter with Peltier Compensation

A. Velázquez-Campoy, O. López-Mayorga, M. A. Cabrerizo-Vílchez

Journal:

Journal of Thermal Analysis and Calorimetry

Year:

1999

Language:

english

File:

PDF, 149 KB

english, 1999

19

Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor

Adrian Velazquez-Campoy, Irene Luque, Matthew J. Todd, Mark Milutinovich, Yoshiaki Kiso, Ernesto Freire

Journal:

Protein Science

Year:

2000

Language:

english

File:

PDF, 344 KB

english, 2000

20

The Binding Energetics of First- and Second-Generation HIV-1 Protease Inhibitors: Implications for Drug Design

Adrian Velazquez-Campoy, Yoshiaki Kiso, Ernesto Freire

Journal:

Archives of Biochemistry and Biophysics

Year:

2001

Language:

english

File:

PDF, 173 KB

english, 2001

21

Stability and binding of the phosphorylated species of the N-terminal domain of enzyme I and the histidine phosphocarrier protein from the Streptomyces coelicolor phosphoenolpyruvate:sugar phosphotransferase system

Rosa Doménech, Ana Isabel Martínez-Gómez, David Aguado-Llera, Sergio Martínez-Rodríguez, Josefa María Clemente-Jiménez, Adrián Velázquez-Campoy, José L. Neira

Journal:

Archives of Biochemistry and Biophysics

Year:

2012

Language:

english

File:

PDF, 806 KB

english, 2012

22

Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets

Hiroyasu Ohtaka, Salman Muzammil, Arne Schön, Adrian Velazquez-Campoy, Sonia Vega, Ernesto Freire

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2004

Language:

english

File:

PDF, 237 KB

english, 2004

23

GrpE N-terminal Domain Contributes to the Interaction with DnaK and Modulates the Dynamics of the Chaperone Substrate Binding Domain

Fernando Moro, Stefka G. Taneva, Adrián Velázquez-Campoy, Arturo Muga

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 855 KB

english, 2007

24

A Mechanism for Histone Chaperoning Activity of Nucleoplasmin: Thermodynamic and Structural Models

Stefka G. Taneva, Sonia Bañuelos, Jorge Falces, Igor Arregi, Arturo Muga, Petr V. Konarev, Dmitri I. Svergun, Adrián Velázquez-Campoy, María A. Urbaneja

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.92 MB

english, 2009

25

Key Residues at the Riboflavin Kinase Catalytic Site of the Bifunctional Riboflavin Kinase/FMN Adenylyltransferase FromCorynebacterium ammoniagenes

Ana Serrano, Susana Frago, Beatriz Herguedas, Marta Martínez-Júlvez, Adrián Velázquez-Campoy, Milagros Medina

Journal:

Cell Biochemistry and Biophysics

Year:

2013

Language:

english

File:

PDF, 687 KB

english, 2013

26

Zinc induced folding is essential for TIM15 activity as an mtHsp70 chaperone

Hugo Fraga, Elena Papaleo, Sonia Vega, Adrián Velazquez-Campoy, Salvador Ventura

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

27

Binding Thermodynamics of Ferredoxin:NADP+ Reductase: Two Different Protein Substrates and One Energetics

Martínez-Júlvez, Marta, Medina, Milagros, Velázquez-Campoy, Adrián

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 534 KB

english, 2009

28

Partition of Amphiphilic Molecules To Lipid Bilayers By ITC

Moreno, Maria Joao, Bastos, Margarida, Velazquez-Campoy, Adrian

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 61 KB

english, 2010

29

Conformational Stability of Hepatitis C Virus NS3 Protease

Abian, Olga, Vega, Sonia, Neira, Jose Luis, Velazquez-Campoy, Adrian

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 541 KB

english, 2010

30

Exact Analysis of Heterotropic Interactions in Proteins: Characterization of Cooperative Ligand Binding by Isothermal Titration Calorimetry

Velazquez-Campoy, Adrian, Goñi, Guillermina, Peregrina, Jose Ramon, Medina, Milagros

Journal:

Biophysical Journal

Year:

2006

Language:

english

File:

PDF, 3.00 MB

english, 2006

31

Structural Characterization of Myotoxic Ecarpholin S From Echis carinatus Venom

Zhou, Xingding, Tan, Tien-Chye, Valiyaveettil, S., Go, Mei Lin, Manjunatha Kini, R., Velazquez-Campoy, Adrian, Sivaraman, J.

Journal:

Biophysical Journal

Year:

2008

Language:

english

File:

PDF, 1.41 MB

english, 2008

32

Defining the Epitope Region of a Peptide from the Streptomyces coelicolor Phosphoenolpyruvate:Sugar Phosphotransferase System Able to Bind to the Enzyme I

Hurtado-Gómez, Estefanía, Abián, Olga, Muñoz, F. Javier, Hernáiz, María José, Velázquez-Campoy, Adrián, Neira, José L.

Journal:

Biophysical Journal

Year:

2008

Language:

english

File:

PDF, 494 KB

english, 2008

33

The Mechanism of Allosteric Coupling in Choline Kinase α1 Revealed by the Action of a Rationally Designed Inhibitor

Sahún-Roncero, María, Rubio-Ruiz, Belén, Saladino, Giorgio, Conejo-García, Ana, Espinosa, Antonio, Velázquez-Campoy, Adrián, Gervasio, Francesco Luigi, Entrena, Antonio, Hurtado-Guerrero, Ramon

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

34

Overcoming drug resistance in HIV-1 chemotherapy: The binding thermodynamics of Amprenavir and TMC-126 to wild-type and drug-resistant mutants of the HIV-1 protease

Hiroyasu Ohtaka, Adrian Velázquez-Campoy, Dong Xie, Ernesto Freire

Journal:

Protein Science

Year:

2002

Language:

english

File:

PDF, 243 KB

english, 2002

35

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase

Chopra, Shaileja, Palencia, Andrés, Virus, Cornelia, Tripathy, Ashutosh, Temple, Brenda R., Velazquez-Campoy, Adrian, Cusack, Stephen, Reader, John S.

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 1.23 MB

english, 2013

36

Synthesis and Characterization of a Lipidic Alpha Amino Acid: Solubility and Interaction with Serum Albumin and Lipid Bilayers

Filipe, Hugo A. L., Coreta-Gomes, Filipe M., Velazquez-Campoy, Adrian, Almeida, Ana R., Peixoto, Andreia F., Pereira, Mariette M., Vaz, Winchil L. C., Moreno, Maria J.

Journal:

Journal of Physical Chemistry B

Year:

2013

Language:

english

File:

PDF, 618 KB

english, 2013

37

Improved Flavodoxin Inhibitors with Potential Therapeutic Effects against Helicobacter pylori Infection

Galano, Juan J., Alías, Miriam, Pérez, Reyes, Velázquez-Campoy, Adrian, Hoffman, Paul S., Sancho, Javier

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.19 MB

english, 2013

38

Therapeutic Strategies for Gaucher Disease: Miglustat (NB-DNJ) as a Pharmacological Chaperone for Glucocerebrosidase and the Different Thermostability of Velaglucerase Alfa and Imiglucerase

Abian, Olga, Alfonso, Pilar, Velazquez-Campoy, Adrian, Giraldo, Pilar, Pocovi, Miguel, Sancho, Javier

Journal:

Molecular Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 532 KB

english, 2011

39

Structure of GrlR–GrlA complex that prevents GrlA activation of virulence genes

Padavannil, Abhilash, Jobichen, Chacko, Mills, Erez, Velazquez-Campoy, Adrian, Li, Mo, Leung, Ka Yin, Mok, Yu Keung, Rosenshine, Ilan, Sivaraman, J.

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

40

Isolated noncatalytic and catalytic subunits of F1-ATPase exhibit similar, albeit not identical, energetic strategies for recognizing adenosine nucleotides

Salcedo, Guillermo, Cano-Sánchez, Patricia, de Gómez-Puyou, Marietta Tuena, Velázquez-Campoy, Adrián, García-Hernández, Enrique

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2014

Language:

english

File:

PDF, 904 KB

english, 2014

41

Amplification of the Effects of Drug Resistance Mutations by Background Polymorphisms in HIV-1 Protease from African Subtypes †

Velazquez-Campoy, Adrian, Vega, Sonia, Freire, Ernesto

Journal:

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

42

Kinetics and Thermodynamics of Chlorpromazine Interaction with Lipid Bilayers: Effect of Charge and Cholesterol

Martins, Patrícia T., Velazquez-Campoy, Adrian, Vaz, Winchil L. C., Cardoso, Renato M. S., Valério, Joana, Moreno, Maria João

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 702 KB

english, 2012

43

Applications of Isothermal Titration Calorimetry in the Characterization of the Energetics, and Kinetics, of the Interaction of Amphiphiles with Lipid Bilayers

Moreno, Maria Joao, Martins, Patrícia T., Velazquez-Campoy, Adrian

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 39 KB

english, 2013

44

The C-terminal extension of bacterial flavodoxin-reductases: Involvement in the hydride transfer mechanism from the coenzyme

Bortolotti, Ana, Sánchez-Azqueta, Ana, Maya, Celia M., Velázquez-Campoy, Adrián, Hermoso, Juan A., Medina, Milagros, Cortez, Néstor

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2014

Language:

english

File:

PDF, 2.10 MB

english, 2014

45

Thermodynamics of Chlorpromazine Association with Lipid Bilayers

Martins, Patrícia A.T., Velazquez-Campoy, Adrián, Vaz, Winchil L.C., Moreno, Maria João

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 62 KB

english, 2011

46

Recombinant production of human ICAM-1 chimeras by single step on column refolding and purification

Núñez, David, Domingo, María Pilar, Sánchez-Martínez, Diego, Cebolla, Vicente, Chiou, Arthur, Velázquez-Campoy, Adrián, Pardo, Julián, Gálvez, Eva Ma

Journal:

Process Biochemistry (Elsevier)

Year:

2013

Language:

english

File:

PDF, 1.53 MB

english, 2013

47

Low-density lipoprotein receptor is a calcium/magnesium sensor - role of LR4 and LR5 ion interaction kinetics in low-density lipoprotein release in the endosome

Martínez-Oliván, Juan, Rozado-Aguirre, Zuriñe, Arias-Moreno, Xabier, Angarica, Vladimir E., Velázquez-Campoy, Adrián, Sancho, Javier

Journal:

Year:

2014

Language:

english

File:

PDF, 2.07 MB

english, 2014

48

Structural Basis for the Interaction of Unstructured Neuron Specific Substrates Neuromodulin and Neurogranin with Calmodulin

Kumar, Veerendra, Chichili, Vishnu Priyanka Reddy, Zhong, Ling, Tang, Xuhua, Velazquez-Campoy, Adrian, Sheu, Fwu-Shan, Seetharaman, J., Gerges, Nashaat Z., Sivaraman, J.

Journal:

Scientific Reports

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013

49

Cytochrome c1 exhibits two binding sites for cytochrome c in plants

Moreno-Beltrán, Blas, Díaz-Quintana, Antonio, González-Arzola, Katiuska, Velázquez-Campoy, Adrián, De la Rosa, Miguel A., Díaz-Moreno, Irene

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2014

Language:

english

File:

PDF, 2.88 MB

english, 2014

50

Mechanism of FMN Binding to the Apoflavodoxin from Helicobacter pylori

Ayuso-Tejedor, S., Abián, O., Velázquez-Campoy, A., Sancho, J.

Journal:

Year:

2011

Language:

english

File:

PDF, 770 KB

english, 2011

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